Abstract
Isoquercetin is a biologically active, naturally occurring flavonol, with multiple potential clinical applications against bladder cancer. Isoquercetin can be administered both as a supplement and as an active pharmacological principle, and exerts potent antioxidant, anti-thrombotic, anti-inflammatory as well as anti-proliferative effects in vivo. As a supplement, isoquercetin may be consumed for prevention of bladder cancer recurrence in high- risk patients. As a drug, isoquercetin has shown promising activity as an anti-thrombotic and as an anti-fatigue agent in cancer patients, and it may be of use in patients with metastatic bladder cancer. Finally, isoquercetin may enhance BCG efficacy in patients with localized cancer undergoing intravesical adjuvant therapy. In conclusion, isoquercetin represents an attractive nutritional and pharmacological agent for the management of bladder cancer. Further epidemiological studies and clinical trials are warranted.
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