Abstract
Phytochemical investigation of Ephedra viridis (whole plant) led to the isolation of four lignans including (+)-9-acetoxyisolariciresinol, which is a new lignan, lariciresinol, 9-acetoxylariciresinol and isolariciresinol. All the isolates were tested for their antioxidant activity and cytotoxicity against a panel of solid tumor and human leukemia cells. They were also screened for estrogenic activity using a recombinant yeast estrogen screening (YES) assay. Most of the lignans exhibited moderate antioxidant activity without any cytotoxicity. None of them were estrogenic in the YES assay.
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