Abstract
The chemical composition and biological activity of a sample of Saudi Arabian propolis were investigated. A new diterpene propsiadin ((ent)-2-oxo-kaur-16-en-6,18-diol) (3) along with the flavonoids 3,4-dihydro-2-(3,4-dihydroxyphenyl)-2H-chromene-3,7-diol (1), psiadiarabin (2) and the diterpene psiadin (4) were isolated from a Saudi Arabian propolis. Their structures were determined by HR-ESI-MS, 1D and 2D NMR. Compound 1 was inactive against Trypanosoma brucei and Mycobacterium marinum while compounds 2–4 had MICs of 30.9, 78.1 and 78.1μM against T. brucei respectively and 312.1, 312.1 and 69.1μM against M. marinum. The likely sources of the propolis are Psiadia arabica and Psiadia punctulata and it represents a new type of propolis not described before.
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