Abstract
Objectives: The present work was designed to investigate the phytochemical and in vitro screening of the flower extracts of Mirabilis jalapa.
 Materials and Methods: Phytochemical constituents were isolated using column chromatography and characterized of the compounds were carried out using IR, 1H NMR, 13C NMR and mass spectroscopy data. In vitro anti-diabetic activity was evaluated by alpha-amylase inhibition assay and Alpha-glucosidase inhibition assay.
 Results: Phytochemical investigation of the ethanol extract revealed the presence of a flavonoid Kaempferol and a triterpenoid Lupeol. In vitro investigation indicated that the Mirabilis jalapa flowers extracts has considerable anti-diabetic activity
 Conclusion: The anti-diabetic activity may due to the presence of phytoconstituents like flavonoids, triterpenoids, steroids.
Highlights
Utilization of plants as medicines is the earliest remedies known to human
C=O Str was observed at 1725.41 cm-1, C=C at 1653.09 cm-1 and C-O-C at 1202.32 cm-1.In the 1H NMR spectra the protons of the hydroxyl groups were indicated at δ9.24ppm - δ12.44 ppm. 21H appeared at δ 8.042 ppm, 61-H at δ 6.93 ppm, 31-H at δ 6.90 ppm, 8-H at δ 6.89 ppm, 6-H at δ 6.40 ppm and 51-H at δ 6.18 ppm
The compound was identified as Kaempferol which was confirmed by IR, 1H NMR,13C NMR and Mass spectral characters and by chromatography with an authentic sample of Kaempferol [13]
Summary
Utilization of plants as medicines is the earliest remedies known to human. Ayurveda and Chinese traditional medicine are the two main systems which utilize herbal medicines as remedies. Herbal medical system is considered as fundamental framework for the modern pharmaceutical drug regimen. In olden days medicines derived from plants were used for treatment, there was no allopathic system of medications. Once the allopathic system was developed the popularity of herbals decreased due to the rapid action of drugs. Demand for plant based medicines have increased in last two decades due to limitations of allopathic medicines [1]. More than 25% of prescribed drugs contain plant based API’s. Almost 70% of medicines used in India are derived from plants [2]
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