ISOLATION, CHARACTERIZATION AND ANTIMYCOBACTERIAL POTENCY OF A FURAN DERIVATIVE FROM THE CHLOROFORM CRUDE EXTRACT OF Icacina trichantha oliv TUBER.

Abstract

Spectroscopic analysis of a pure isolate (OAU 2, a furan derivative) by column chromatography from the chloroform crude extract of Icacina trichantha tuber was done using FT-IR, 1HNMR, 13CNMR, COSY and was established by literature as well as the investigation of antimycobacterial potency. This anitmycobacterial activity revealed that this isolate actually has activity against DR-TB Strain and H37RV Strain which are American type culture collection strain and multi-drug resistant strains of M. tuberculosis being the test organisms. Hence, confirming the folk believe of the use of I. trichantha tuber in the treatment of “serious cough”