Isolation and structure revision of 10-deacetyltaxinine from the seeds of the Chinese yew, Taxus mairei

Abstract

A new taxoid was isolated from the methanol extract of the seeds of Taxus mairei. Its structures were established as 2α,9α-diacetoxy-10β-hydroxy-5α-cinnamoyloxytaxa-4(20), 1l-dien-13-one (l0-deacetyltaxinine, 1) on the basis of spectral analysis including 1H-NMR, 13C-NMR, HMQC, HMBC, NOESY, and HR-FABMS. The structure of previously reported l0-deacetyltaxinine is 9-deacetyltaxinine.