Abstract
Cyanobacteria, commonly known as blue-green algae, have provided a variety of novel bioactive natural products. As part of our ongoing natural product drug discovery project, we evaluated organic extracts of cultured cyanobacteria for cytotoxicity against the HT-29 human colon carcinoma cell line. The organic extract of cyanobacterium Oscillatoria sp. (UIC 10045) displayed significant activity in this assay. LC-MS-NMR dereplication indicated the activity to be associated with a potentially new peptide. Bioassay guided fractionation led to the isolation of this peptide. The structure was determined by a combination of 1D/2D NMR spectroscopic techniques and HRESIMS as a dodeca lipopeptide with three non-standard amino acids and one β-amino acid residue. The structure elucidation and biological activities of the compound will be presented.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
