Abstract
Extracts of the fungus, Fusarium tricinctum, isolated from toxic moldy corn, produced severe edema and intradermal hemorrhage when applied to rat skin. Purification studies guided by this test led to the isolation of a major toxin in crystalline form plus a second amorphous toxic product. The crystalline material, C 17H 24O 6, appeared to be an hydroxy ester or lactone, and was highly active in doses of 0.5 mg per animal. It is not the same as any of the toxins previously found in Fusarium species from moldy grains, and does not resemble the aflatoxin group.
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