Abstract
1. 1. A macromolecular aggregate associated with bile pigments has been isolated from human gallbladder and hepatic bile, using isopycnic gradient ultracentrifugation in caesium chloride. Sixty-six percent of the total bile pigments, 66% of the total cholesterol, 69% of the total phospholipids and 65% of the total bile salts present in bile were associated with this polymolecular aggregate. 2. 2. The percentage contribution of each of the components measured in the macromolecule was 14.5% cholesterol, 16% phospholipids, 66% bile salts, 3% bile pigments and 0.5% protein. 3. 3. The molecular weights of the macromolecular aggregate varied with the source of the bile, being from 11000 to 20000 in hepatic bile; from 35000 to 75000 in bile samples from gallbladders containing gallstones; and from 65000 to 75000 in bile samples from normal gallbladders. The molecular weight of the aggregate varied with the concentration of the bile. Heavier complexes were present in the more concentrated bile samples. 4. 4. It was suggested that the macromolecule represented the micellar aggregation of cholesterol, phospholipids, bile salts and pigment in bile.
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