Abstract
Isolating the Effects of Mg2+, Mn2+ and Sr2+ Ions on Osteoblast Behavior from those Caused by Hydroxyapatite Transformation
Highlights
The insertion of trace elements into the hydroxyapatite structure [Ca10(PO4)6(OH)2] is widely proposed as an important way to improve the biocompatibility of bone grafts and implants used in the treatment of bone diseases[1,2,3]
Being multisubstituted, biomineralized hydroxyapatite is very different from typical hydroxyapatites synthesized in the laboratories, and it is easier to evaluate the effect of one element on the cells if this element is the only dopant in the structure
In a previous work[31], we demonstrated that the amounts of Sr2+, Mg2+ and Mn2+ ions present in the precipitated hydroxyapatite phase were not similar
Summary
The insertion of trace elements into the hydroxyapatite structure [Ca10(PO4)6(OH)2] is widely proposed as an important way to improve the biocompatibility of bone grafts and implants used in the treatment of bone diseases[1,2,3]. Being multisubstituted, biomineralized hydroxyapatite is very different from typical hydroxyapatites synthesized in the laboratories, and it is easier to evaluate the effect of one element on the cells if this element is the only dopant in the structure. For this reason, the isolated effects of trace elements on cells, cells in bone tissue, have been continuously studied. Mn2+ is involved in the regulation of Materials Research group and the pristine group This difference was attributed to the biological role of the Fe and Sr ions released from the ceramic over time. Many of the effects attributed to one specific element in the doped hydroxyapatites on cellular behavior or in vivo performance are not adequately explained
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