Abstract
The ophthalmic evaluation may indicate early relapses of acute lymphoblastic leukemia (ALL) even in the presence of normal cerebrospinal fluid (CSF) cytology, blood, and bone marrow parameters. A high degree of suspicion in patients having visual dysfunction in ALL may help in early diagnosis and prompt initiation of treatment. We present a case series of five ALL patients with optic nerve head (ONH) involvement as the first sign of central nervous system (CNS) relapse with normal CSF, blood, and bone marrow parameters Though it is difficult to objectively specify a window period during which initiation of treatment can maximize the chances of visual recovery, we can emphasize that prompt initiation of treatment (preferably not exceeding more than a week interval) might have a more favorable visual outcome. We present a case series of five ALL patients with ONH involvement as the first sign of CNS relapse with normal CSF, blood, and bone marrow parameters.
Published Version
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