Abstract
The paper describes the design of an isolated microelectrode amplifier system used for transmembrane potential measurements in papillary muscle. A pulsed high-frequency alternating current, obtained from a power amplifier, is passed through the preparation to obtain positive temperature steps. The need for isolation of the microelectrode amplifier became imperative when the preparation was to be raised in temperature by high power application in the muscle tissue with ratings up to 50 W at a frequency of 30 MHz. Application of the isolation principle allows measurements without significant interference up to and beyond this frequency. The bandwidth of the amplifier system is 34 kHz and the accuracy is 0·1 per cent to make the system suitable for simultaneous temperature measurement with the microelectrode.
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