Isolated APTT prolongation-not always a bleeding risk in acute paediatric burns surgery.

M Nizamoglu,U Anwar,S Bhandari,K S Alexander

doi:10.1007/s00238-014-1012-y

M Nizamoglu, U Anwar + Show 2 more

Open Access

https://doi.org/10.1007/s00238-014-1012-y

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Abstract

Isolated APTT prolongation-not always a bleeding risk in acute paediatric burns surgery.

Highlights

Sir, There are several causes of isolated elevated activated partial thromboplastin time (APTT), some of which are known to cause increased bleeding
Dilute Russell’s viper venom time (DRVVT), a test used for the detection of lupus anticoagulant and antiphospholipid antibody including
Deficiencies in contact factors, factors 8, 9, 11 and 12 deficiencies, all result in an isolated APTT prolongation, as well as lupus anticoagulant, anticardiolipin, Von Willebrand disease and acquired clotting factor inhibitors such as acquired haemophilia A

Summary

Introduction

There are several causes of isolated elevated activated partial thromboplastin time (APTT), some of which are known to cause increased bleeding. After the haematologist advised blood cultures, meningococcal/pneumococcal PCR; viral screens and clotting factor 8, 9, 11 and 12 assays were tested and shown to be normal. Her APTT was 185 s when repeated using the SynthASil reagent, which has greater sensitivity to contact factor deficiencies.

Results

Conclusion