Abstract
Isoflurane in the Aged Brain: A Link to Altered Amyloid Precursor Protein Processing
Highlights
General anaesthesia may give rise to post-operative cognitive dysfunction and/or be a precursor to the development or progression of neurodegenerative processes such as Alzheimer’s disease (AD) [13]
Aged wild-type mice were exposed to the two anaesthesia paradigms; the respiratory rate of all mice was continuously monitored whilst under anaesthesia and care was given to maintain body temperature
This study focused on the biomarkers of the AD neurodegenerative process
Summary
General anaesthesia may give rise to post-operative cognitive dysfunction and/or be a precursor to the development or progression of neurodegenerative processes such as Alzheimer’s disease (AD) [13]. There continues, to be debate in the field around this issue, and around the potential mechanisms by which anaesthetics may contribute to the pathophysiology of AD (for a review, see [16]). This has prompted ongoing research at the basic science level
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