Abstract
SUMMARY 1 The aim of the present study was to assess the effects of isoflavone aglycones (IFA; AglyMaxTM; Nichimo Co. Ltd, Tokyo, Japan), containing 32.9% IFA, on the production of nitric oxide (NO) and systolic blood pressure (SBP) in stroke-prone spontaneously hypertensive rats (SHRSP). 2 Twelve male SHRSP rats, aged 5 weeks, were used. Rats were divided into two groups: (i) the IFA group (n = 6); and (ii) the control group (n = 6). Administration of IFA (20 mg/kg equivalent of isoflavones) resulted in a significant decrease in SBP in the IFA-treated group compared with the control group. 3 Nitric oxide levels in the urine and serum were also significantly higher in the IFA-treated group than in the control group. Significantly higher levels of endothelial NO synthase mRNA were also confirmed in the IFA group compared with the control group. 4 Isoflavone aglycones could decrease SBP significantly by increasing the formation of NO.
Published Version
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