Abstract
Type 1 Diabetes (T1D) is one of the most common chronic diseases in childhood, which is caused by destruction of insulinproducing pancreatic beta cells. Its incidence increases 3-5% annually and doubles every 20 years [1,2]. On one hand, acute and chronic complications of T1D seriously affect the quality of life and even life span of patients. On the other hand, prognosis can greatly be improved when the disease prediction and closely monitoring are applied, leading to earlier diagnosis and treatment [3]. Islet Autoantibodies (IAbs), as most reliable biomarkers at present for islet autoimmunity, precede clinical T1D by years and play an essential role in prediction and clinical diagnosis of T1D [4,5].
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