Ischemic Pretreatment Increases Cytoskeletal Association of 25 kD and 70 kD Heat-Shock Proteins and of Na,K-ATPase in Rat Renal Cortex after Repeat Ischemia † 1786

Abstract

Ischemia results in increased induction of 25 kD and 70 kD HSPs in renal cortex. Recent research suggests interactions of these HSPs with cytoskeletal elements during the restoration of cellular polarity. To determine whether pretreatment with ischemia protects the membrane-cytoskeletal complex after repeat renal ischemia, we investigated cellular distribution of 25 kD and 70 kD HSPs and of Na,K-ATPase after a single and after repeat ischemia (45 min) in rat renal cortex.