Abstract
Objectives: The present study was designed to evaluate the toxic effect of GA3 on the renal cortex of rats and to assess the possibility of recovery after GA3 withdrawal. Materials and Methods: Rats (n = 50) were classified into 5 groups: group 1 (control) received no treatment, animals belonging to group 2 and group 3 were respectively given GA3 at doses of 100 and 200part per million (ppm) daily for eight weeks in drinking water. Animals of recovery groups (group 4 and group 5) were remained for eight weeks without treatment after receiving 100 and 200 ppm of GA3 in drinking water for eight weeks respectively. Rats were dissected; kidney samples were collected and processed for histopathological and ultrastructural studies. Results: The renal cortex of GA3-treated rats exhibited its apparent toxic effect on renal corpuscles and renal convoluted tubules associated with fibrosis. These observations confirmed by the ultrastructure examination of renal cortical tissues. The Renal cortex from animals treated with 200 ppm GA3 revealed more severe structural changes. However, eight weeks of GA3 withdrawing has resulted in some regression of the pathological changes. Conclusion: GA3 has dose-dependent toxic effects. While stop giving of GA3 for eight weeks revealed incomplete recovery of its harmful effects. Therefore, exposure to GA3 should be limited. Keywords: Plant Growth Regulators, Gibberellic Acid Toxicity, Renal Cortex, Ultrastructure, Rats
Highlights
The plant growth regulators (PGRs) are among the several chemicals that are widely used in agriculture nowadays
This study was conducted on 50 adult male albino rats (Rattus norvegicus), weighting (170–200 g) were obtained from an animal house in College of Veterinary Medicine, Indian Journal of Science and Technology
There were highly increased intraglomerular mesangial matrix collagen fibrils associated with fibrosis around the renal corpuscle and convoluted tubules (Figure 2c)
Summary
The plant growth regulators (PGRs) are among the several chemicals that are widely used in agriculture nowadays. It started to be used in the 1930s [1]. PGRs regulate plant growth, they are known as phytohormones or plant growth hormones [2]. According to the American Society of Agricultural Science and gibberellins are one of the six major classes of plant growth regulators [3]. Gibberellic acid (GA3) is used to increase. El-Mancy the growth of some vegetables such as pepper, tomatoes, and olive and fruits such as date palm, grapes and strawberries [4]
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