Abstract
Ischemic exercise testing is used in evaluation of patients with suspected McArdle disease, also known as glycogen storage disease type V (1). Lack of an increase in the blood lactate concentration during exercise is indicative of a defect in conversion of glycogen (or glucose) to lactate, consistent with the deficiency of skeletal muscle phosphorylase in this disease. Other glycogen storage diseases, such as deficiencies of phosphofructokinase and debranching enzyme, would also yield an abnormal ischemic exercise response. In anticipation of performing the ischemic exercise test on a suspected case, one of us (S.D.R.) carried out the test …
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