Abstract
BackgroundThymoquinone is one of the active ingredients of blackcumin (Nigella sativaL.) essential oil possessing anti-inflammatory, antineoplastic, neuro- and hepatoprotec-tive properties. Some of these properties were attributedto an antioxidant activity of thymoquinone, which seemsto be unlikely from its structure. Because the lipophilicthymoquinone exhibits a structural similarity with thenatural mitochondrial electron carrier, ubiquinone, itwas of interest whether the suggested antioxidant effectof thymoquinone in cells can be explained by its interac-tion with the mitochondrial respiratory chain.Materials and methodsAntioxidant activities were determined spectrophotome-trically by means of the 2,2-diphenyl-1-picrylhydrazyl-radical (DPPH
Highlights
Thymoquinone is one of the active ingredients of black cumin (Nigella sativa L.) essential oil possessing antiinflammatory, antineoplastic, neuro- and hepatoprotective properties. Some of these properties were attributed to an antioxidant activity of thymoquinone, which seems to be unlikely from its structure
Because the lipophilic thymoquinone exhibits a structural similarity with the natural mitochondrial electron carrier, ubiquinone, it was of interest whether the suggested antioxidant effect of thymoquinone in cells can be explained by its interaction with the mitochondrial respiratory chain
The cytochrome c system turned out to be unsuitable for the evaluation of the antioxidant activity of thymoquinone
Summary
Thymoquinone is one of the active ingredients of black cumin (Nigella sativa L.) essential oil possessing antiinflammatory, antineoplastic, neuro- and hepatoprotective properties. Some of these properties were attributed to an antioxidant activity of thymoquinone, which seems to be unlikely from its structure. Because the lipophilic thymoquinone exhibits a structural similarity with the natural mitochondrial electron carrier, ubiquinone, it was of interest whether the suggested antioxidant effect of thymoquinone in cells can be explained by its interaction with the mitochondrial respiratory chain
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