Abstract
In this study, it was aimed to compare the effect of clinical, radiological, and thermographic methods on the diagnosis and prognosis in experimentally rats with arthritis. A total of 24 rats were divided into 2 groups, each consisting of 12 rats. Arthritis was formed by administering 0,1 ml of FCA solution to the left-back extremities of the rats. The first group was called the control group. Cephalexin (60 mg/kg) and Diclofenac Sodium (1mg/kg) were applied to the second group to be the treatment group. From day 1 of the experiment, clinical evaluation and live weight measurements were performed every day. On the 7th, 14th, 21st, 28th days of the experiment, paw edema, radiographic, thermographic measurements were performed. While typical arthritis clinical findings obtain after FCA administration, no statistically significant difference was found when analyzing the changes of live weight measurements and paw edema measurements according to groups and time. The difference in the mean of the thermographic measurements of the arthritis-forming claws was statistically significant. Radiographically, degenerations in the joints and bones were found in the control group compared to the more in the treatment group. As a result, it was concluded that thermography can be a good alternative to clinical findings and radiography in the follow-up of arthritis.
Highlights
Arthritis is the inflammation of one or more of the Alkan, 2002)
While typical arthritis clinical findings obtain after FCA administration, no statistically significant difference was found when analyzing the changes of body weight measurements and paw edema measurements according to groups and time
The significant increase in local temperature in arthritis cases, which can be seen in all animal species and may progress with bone destruction, has led to the use of thermography, which is one of the imaging methods
Summary
Arthritis is the inflammation of one or more of the Alkan, 2002). While no finding can be determined by structures that make up the joint. Direct radiography in acute arthritis, the earliest finding the joint cartilages lose their clarity while their color in acute septic arthritis is joint effusion The first radiographic continue, abrasions, which can vary from microscopic findings are determined 24 hours after the disease measurements to a few mm, are formed on the occurs and begin to occur within 5-10 days at the cartilage surface (Samsar and Akın, 2003). There is an increase in joint volume during this radiological, and synovial fluid examinations are period, but the radiographic data are not clear (Bumin routinely used for diagnosis of arthritis (Gökhan and et al, 2001). The most important criterion of joint -5 weeks At this stage, thickening of the joint capsule radiography is the visualization of the joint space. The and increase in opacity, lytic changes in the width and stenosis of the joint space may differ with subchondral bone, periarticular osteopenia, alignment the movement or position of the joint
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