Abstract

To evaluate whether there is an effect of the physician who transfers the embryos on pregnancy rates in in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) treatment. A total of 757 participants were analyzed between 2012 and 2017. Participants were classified according to 3 physicians who transferred the embryos: ([group 1 = 164 patients]; [group 2 = 233 patients]; [group 3 = 360 patients]). Baseline parameters and IVF-ICSI outcomes were compared between the groups. No differences were determined between the groups regarding the baseline parameters (age, age subgroups [20-29, 30-39, and ≥ 40 years old)], body mass index (BMI), smoking status, infertility period, cause of infertility, baseline follicle stimulating hormone, luteinizing hormone, estradiol (E2), thyroid stimulating hormone, prolactin levels, antral follicle count, duration of stimulation, stimulation protocol, gonadotropin dose required, maximum E2 levels, progesterone levels, endometrial thickness on human chorionic gonadotropin (hCG) administration and transfer days (p > 0.05). The numbers of oocytes retrieved, metaphase II (MII), 2 pronucleus (2PN), , transferred embryo, fertilization rate, day of embryo transfer, the catheter effect and embryo transfer technique, and clinical pregnancy rates (CPRs) were also comparable between the groups (p > 0.05). Our data suggests that the physician who transfers the embryos has no impact on CPRs in patients who have undergone IVF-ICSI, but further studies with more participants are required to elucidate this situation.

Highlights

  • No differences were determined between the groups regarding the baseline parameters], body mass index (BMI), smoking status, infertility period, cause of infertility, baseline follicle stimulating hormone, luteinizing hormone, estradiol (E2), thyroid stimulating hormone, prolactin levels, antral follicle count, duration of stimulation, stimulation protocol, gonadotropin dose required, maximum E2 levels, progesterone levels, endometrial thickness on human chorionic gonadotropin administration and transfer days (p > 0.05)

  • Our data suggests that the physician who transfers the embryos has no impact on clinical pregnancy rate (CPR) in patients who have undergone in vitro fertilization (IVF)-ICSI, but further studies with more participants are required to elucidate this situation

  • There was no difference between the groups regarding age, age subgroups (20–29, 30–39, and ! 40 years old), BMI, smoking status, infertility period, cause of infertility, baseline follicle-stimulating hormone (FSH), luteinizing hormone (LH), E2, thyroid-stimulating hormone (TSH), prolactin levels, antral follicle count, stimulation day, stimulation protocol, gonadotropin dose required, maximum E2 and progesterone levels, and endometrial thickness on human chorionic gonadotropin (hCG) administration and transfer days (p > 0.05)

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Summary

Introduction

Despite all of the developments in assisted reproductive technology (ART) since the first live birth following in vitro fertilization (IVF) in 1978, pregnancy rates have remained at between $ 35 and 45%.1–5 In ART cycles, the method of embryo transfer (ET) is important for clinical pregnancy success in addition to features such as age, endometrial receptivity of the infertile woman, and embryo quality.[6,7,8,9] It has been claimed that faulty ET is responsible for between 25 and 30% of failed implantations, related either to the catheter application technique or to the experience of the clinician performing the ET procedure.[5,6,10] To minimize possible negative effects of different physicians on the clinical pregnancy rate (CPR) in ET, these procedures have been standardized by assisted reproduction clinics. Despite all of the developments in assisted reproductive technology (ART) since the first live birth following in vitro fertilization (IVF) in 1978, pregnancy rates have remained at between $ 35 and 45%.1–5. In ART cycles, the method of embryo transfer (ET) is important for clinical pregnancy success in addition to features such as age, endometrial receptivity of the infertile woman, and embryo quality.[6,7,8,9] It has been claimed that faulty ET is responsible for between 25 and 30% of failed implantations, related either to the catheter application technique or to the experience of the clinician performing the ET procedure.[5,6,10] To minimize possible negative effects of different physicians on the clinical pregnancy rate (CPR) in ET, these procedures have been standardized by assisted reproduction clinics. Some studies have suggested that the physician who performs the ET may affect CPR success.[11,12,13] In the present study, we aimed to evaluate the effect of the physician who transfers the embryos on pregnancy rates in IVF-intracytoplasmic sperm injection (IVF-ICSI) treatment

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