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Abstract
BackgroundAlthough the Brief Psychiatric Rating Scale (BPRS) is widely used for evaluating patients with schizophrenia, it has limited value in estimating the clinical weight of individual symptoms. The aim of this study was 4-fold: 1) to investigate the relationship of the BPRS to the Clinical Global Impression-Schizophrenia Scale (CGI-SCH), 2) to express this relationship in mathematical form, 3) to seek significant symptoms, and 4) to consider a possible modified BPRS subscale.MethodsWe evaluated 150 schizophrenia patients using the BPRS and the CGI-SCH, then examined the scatter plot distribution of the two scales and expressed it in a mathematical equation. Next, backward stepwise regression was performed to select BPRS items that were highly associated with the CGI-SCH. Multivariate regression was conducted to allocate marks to individual items, proportional to their respective magnitude. We assessed the influence of modifications to the BPRS in terms of Pearson's r correlation coefficient and r-squared to evaluate the relationship between the two scales. Utilizing symptom weighting, we assumed a possible BPRS subscale.ResultsBy plotting the scores for the two scales, a logarithmic curve was obtained. By performing a logarithmic transformation of the BPRS total score, the curve was modified to a linear distribution, described by [CGI-SCH] = 7.1497 × log10[18-item BPRS] - 6.7705 (p < 0.001). Pearson's r for the relationship between the scales was 0.7926 and r-squared was 0.7560 (both p < 0.001). Applying backward stepwise regression using small sets of items, eight symptoms were positively correlated with the CGI-SCH (p < 0.005) and the subset gave Pearson's r of 0.8185 and r-squared of 0.7198. Further selection at the multivariate regression yielded Pearson's r of 0.8315 and r-squared of 0.7036. Then, modification of point allocation provided Pearson's r of 0.8339 and r-squared of 0.7036 (all these p < 0.001). A possible modified BPRS subscale, "the modified seven-item BPRS", was designed.ConclusionsLimited within our data, a logarithmic relationship was assumed between the two scales, and not only individual items of the BPRS but also their weightings were considered important for a linear relationship and improvement of the BPRS for evaluating schizophrenia.
Highlights
The Brief Psychiatric Rating Scale (BPRS) is widely used for evaluating patients with schizophrenia, it has limited value in estimating the clinical weight of individual symptoms
The aim of the present study is 4-fold: 1) to investigate the linearity of the BPRS in relation to its items and mark allocation by examining the reasons for the incongruity between BPRS scores and clinicians’ impressions of symptom severity in schizophrenic patients; 2) to determine a mathematical expression that represents the relationship between the BPRS and the CGI-SCH more precisely; 3) to seek which symptoms are important from a clinical standpoint; and 4) if possible, to construct an example of a possible modified BPRS subscale that is expected to have improved correlation with the CGI-SCH scores compared with the full BPRS within the limitations of the data obtained in this trial
Because the shape of the curve was similar to a logarithmic curve, we performed a logarithmic transformation of the 18-item BPRS total score
Summary
The Brief Psychiatric Rating Scale (BPRS) is widely used for evaluating patients with schizophrenia, it has limited value in estimating the clinical weight of individual symptoms. The aim of this study was 4-fold: 1) to investigate the relationship of the BPRS to the Clinical Global Impression-Schizophrenia Scale (CGISCH), 2) to express this relationship in mathematical form, 3) to seek significant symptoms, and 4) to consider a possible modified BPRS subscale. To evaluate the effects of treatment for schizophrenia, it is important to assign quantitative values to the symptoms. The Brief Psychiatric Rating Scale [2] is one of the standard instruments used most frequently in daily practice for evaluating the severity of schizophrenia. The BPRS includes 18 items and the allocation of marks is defined clearly, as all items have the same range of marks (i.e., 1-7), it is not unusual to find that scores for the BPRS differ widely from those for the CGI-SCH
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