Abstract
Psychiatric disorders represent a major public health problem affecting millions of people worldwide (1). There is a consensus that psychiatric disorders are a consequence of environmental exposure, genetic background, and their interplay. However, relatively few genetic effects have been identified in the past 2 decades. In contrast, since it was first identified that individuals with different 5-HTT genotypes differentially respond to stressful life events in developing depression (2), gene-by-environment interaction research has become an emerging discipline in psychiatric genetics.
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