Abstract
Is RNA critical for the production of TSE infection?
Highlights
The prion hypothesis proposed by Prusiner (1998) stipulates that the causal agent of transmissible spongiform encephalopathies (TSEs) is composed exclusively of an infectious protein (PrPsc) produced after structural conversion of a cellular protein (PrPc)
Paying particular attention to the molecular composition of inocula inducing TSE disease reported in these investigations, I plan to discuss here, how these novel findings complement our previous results (Simoneau et al, 2009)
Our results indicate that this crucial cofactor extracted from 263 K PrPsc is composed of two populations of small RNA having an average length of about 27 and 55 nucleotides
Summary
The prion hypothesis proposed by Prusiner (1998) stipulates that the causal agent of transmissible spongiform encephalopathies (TSEs) is composed exclusively of an infectious protein (PrPsc) produced after structural conversion of a cellular protein (PrPc). A commentary on Recombinant prion protein induces a new transmissible prion disease in wild-type animals. We substantiated the idea that the requirement of a cofactor may be indispensable for the acquisition of converted recombinant prion protein (recPrP) infectivity.
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