Abstract
The process by which transmissible spongiform encephalopathy (TSE) agents, or prions, infect cells is unknown. There are also no effective treatments available for TSE diseases. Studies of cultured cells persistently infected with TSE agents have greatly contributed to understanding these and many other aspects of TSE disease. New cell lines have been developed to increase the repertoire of TSE strains that can be investigated in ex vivo models. Candidates for TSE therapeutics have been identified. Initial events involving the internalization and trafficking of TSE agents and the effect of membranes on the infection process have been examined. Recent progress in these areas is discussed below, which together illustrate the value of cell culture models in the study of prion diseases.
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