Abstract
BackgroundThyroid hormones (THs) are well known for their genomic effects but recently several studies revealed their actions as rapid modulators of membrane receptors. In particular, fast thyroxine effect on GABAa receptors have been reported. We addressed question whether presynaptic mechanisms can be also involved in modulation of GABAergic transmission by thyroxine. MethodsUsing patch-clamp technique we examined fast effects of thyroxine (2μM) onevoked GABAergic postsynaptic currents. ResultsWe found that in addition to the inhibitory effect on IPSC amplitude, thyroxine changed IPSC coefficient of variation (CV). ConclusionThis result suggests involvement of a presynaptic mechanism in thyroxine effect on GABAergic transmission.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
