Abstract
The oxidative status may not only be a cause of diabetes, but also a consequence of diabetes. We aimed to evaluate the relationship between hyperglycemia levels and oxidative status in patients with type 2 diabetes using Total Antioxidant Capacity (TAC), Total Oxidative State (TOS) and Oxidative Stress İndex (OSI).
Highlights
Type 2 diabetes mellitus (T2D) is a disease characterized by insulin deficiency or İnsulin Resistance (IR)
The Total Antioxidant Capacity (TAC) was significantly higher in the control group than the other groups (p = 0.001), the Total Oxidative State (TOS) was significantly higher in Gr B, Gr C and Gr D compared to the other groups (p = 0.004), and the Oxidative Stress İndex (OSI) was significantly lower in the control group compared to the other groups (p = 0.001)
It can be claimed that acute glucose fluctuations are more effective in oxidative stress than chronic hyperglycemia
Summary
Type 2 diabetes mellitus (T2D) is a disease characterized by insulin deficiency or İnsulin Resistance (IR). Boyacı et al Int Arch Endocrinol Clin Res 2021, 7:023 Page 1 of 8 . Incretin deficiency/resistance, hyperglucagonemia, increased glucose reabsorption play important roles [1]. Diabetes is responsible for 11.3% of all deaths. Almost half of these deaths are among people under 60 years of age [2]. The seriousness of this picture raises efforts to study the etiopathogenesis and treatment of diabetes in all areas
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