Abstract
Many studies have found correlations between abnormal MPV and clinical reactivity in a variety of diseases. In the present paper, we sought MPV-related neurological diseases that are less frequently reported in the literature. The electronic medical records of 852 neurological patients with mean platelet volume (MPV) measurements (F = 45%, age = 55.7 ± 18.7, 8–104) were searched after the patients had received a diagnosis of a neurological disease (new and old episodes) according to the nine classes of the International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD-10). A set of consecutive statistical methods (i.e., cluster analysis, segmented regression, linear correlation, propensity score matching, and mixed effects Poisson regression) were used to establish a link between MPV and neurological disease. A statistically significant (p < 0.05) relationship with MPV was found only in pain syndrome patients, with seven out of eight clinically diagnosed migraine episodes. With all other ICD-10 classes of neurological diseases, the effect of MPV was found to be nonsignificant (p > 0.05). MPV may implicate a clinical relationship with pain syndrome and migraine episodes. More complex statistics could help analyse data and find new correlations.
Highlights
The mean platelet volume (MPV) is an measurable haematologic standard parameter
Large platelets are associated with prothrombotic states and cardiovascular disease, whereas small platelets are detected in chronic inflammatory diseases or rheumatoid arthritis [3]
In some studies, there was no statistically significant association between appendicitis and MPV [4,5,6], while in another, the MPV was significantly lower in acute gangrenous appendicitis than in control healthy subjects [7]
Summary
The mean platelet volume (MPV) is an measurable haematologic standard parameter. Many scientists have discussed its interpretation and have found correlations between abnormal MPV and clinical reactivity in a variety of diseases [1]. It is believed that several diseases are associated with MPV changes. Abnormal MPV is associated with poor prognosis in several diseases ( confirmed in our study [2]). The MPV is elevated in rheumatoid arthritis, and its cut-off level was estimated to be 10.4 fL [8]. The interpretation of the MPV is not as straightforward as it might appear [1]. One reason for this might be that there is currently no preanalytical standard when dealing with MPV measurements [9]. Some authors have even demonstrated the high technical
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