Is Mean Platelet Volume a Possible Marker in Acute Peritonitis?

Sena Memnune Ulu,Gulsah Asık,Şeref Yüksel,Ahmet Ahsen,Gökhan Yaman,Abdullah Altuğ,Akif Acay

doi:10.15197/sabad.1.12.03

Sena Memnune Ulu, Gulsah Asık + Show 5 more

Open Access

https://doi.org/10.15197/sabad.1.12.03

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Abstract

MPV (mean platelet volume) is one of the determinants of the platelet function which is situated in the routine complete blood count tests and was shown to be inversely correlated with inflammation. We aimed to evaluate MPV values in patients with peritoneal dialysis and in acute peritonitis attacks. 37 patients with PD and 42 healthy subjects were included in the study. 42 peritonitis attacks of the patients were recorded. C reactive protein (CRP) levels and complete blood count tests were analyzed. Mean MPV values were significantly higher in patients with PD in the stable period compared with the control group (p <0.001). Mean MPV values were significantly lower and CRP values were significantly higher in peritonitis attack periods, compared with the stable period of the same PD patients, both (p <0.001). In the correlation analysis, MPV levels in the peritonitis attack were negatively correlated with CRP levels, hospitalization day, peritoneal fluid and plasma leukocyte count (r= -0.751, p<0.001); (r= -0.355, p=0.002, ; ( r= -0.851, p<0.001) ; (r= - 0.579, p<0.001) respectively. In conclusion, our results suggest that assessment of MPV in acute peritonitis in PD patients may indicate systemic inflammation. MPV may be used as an hepler marker to predict the severity of acute peritonitis.

Highlights

Peritoneal dialysis (PD) is a type of renal replacement therapy which reduces the patient's dependency on dialysis center
All parameters were expressed as mean ± standard deviation unless otherwise stated * Data were expressed as number (%) p
Increased Mean platelet volume (MPV) levels in uremic patients and HD patients were demonstrated before [6,7]. It has not been evaluated in PD patients and peritonitis attacks

Summary

Introduction

Peritoneal dialysis (PD) is a type of renal replacement therapy which reduces the patient's dependency on dialysis center. The most important complication of PD is peritonitis, which is responsible for deaths with a rate of 1-6% [1]. Mean platelet volume (MPV), is one of the platelet function indices [3]. Elevated MPV levels may be seen in cardiac or non-cardiac disorders besides many inflammatory situations [4]. Uremic patients have platelet function disorders due to various reasons. Nasri et al showed increased MPV levels in uremic patients [6]. Asanuma supported these findings by reporting higher MPV values in HD patients than healthy control group [7]. Different findings are available [8]

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