Investigation of Differences In CRP, PCT, WBC and MPV In Gram-Negative, Gram-Positive and Fungal Bloodstream Infections

Abstract

Sepsis, which develops as a result of inflammatory response against infection, is a signicant cause of mortality, especially in patients in intensive care unit. Early diagnosis and effective treatment of bacterial infections is life-saving. The aim of this study was investigate the differences in C-reactive protein (CRP), procalcitonin (PCT), white blood cell count (WBC) and mean platelet volume (MPV) levels in bloodstream infections caused by Gram- negative (GN), Gram-positive (GP) or fungal agents. We retrospectively evaluatd the patients with bloodstream infections hospitalized between 01.01.2014 and 01.01.2016. Identification of microorganisms was performed in Microbiology Laboratory. Blood cultures were performed by using BACTEC 9120 (Becton Dickinson, USA) automatized blood culture system. CRP, PCT, WBC and MPV levels, which were investigated simultaneously with blood culture, of patients in whose blood culture growth occured were investigated. Mean PCT, CRP, WBC and MPV values were compared in patients with different infection agents. A total of 74 patients were investigated. There were 35 (47%) patients with Gram-negative, 26 (35%) patients with Candida and 13 (18%) patients with Gram-positive microorganisms. The most common GN microorganism agents were was Acinetobacter, Candida albicans was the most common fungal agent and coagulase-negative staphylococci (CoNS) was the most common GP agent. The highest PCT values were in patients with Klebsiella, Escherichia coli and Acinetobacter infections, respectively. CRP and PCT values were higher in GN bacteremias compared to GP and fungal infections. We think that CRP and PCT levels may be beneficial for differentiation of GN bacteraemia, GP bacteraemia and fungal infections aand may be considered as a factor which may guide empirical antimicrobial treatments.