Is karyotype beneficial in prenatal non-lethal anomalies?

Abstract

The objective of the study is to evaluate the need for fetal karyotyping after ultrasonographic diagnosis of isolated non lethal anomalies and to stress the importance of prenatal counseling. Sixty expectant mothers were chosen to have detailed fetal anomalies survey including echo were done between 24-28 weeks. The fetuses diagnosed antenately for nonlethal anomalies are subjected to postnatal karyotyping. About twelve cases of isolated nonlethal anomalies were detected. Various anomalies are intra abdominal cyst, VSD, microcephaly, isolated hydrocephalus, cleft lip, cleft palate, talipes, and abnormal wrist position were detected. Out of twelve cases only one case had abnormal Karyotype and it was Trisomy 18. From this study it is concluded, that in isolated Non-Lethal anomalies with otherwise normal morphology, prenatal testing of karyotyping is not beneficial.