Abstract
Introduction/objectiveXerostomia is one of the main symptoms of primary Sjögren's syndrome (pSS). The unstimulated salivary flow (UWS) test is one of the objective Sjögren's syndrome classification criteria used to assess xerostomia's severity. The study’s objective was to evaluate UWS rate measurements (with a threshold rate of 0.1 mL/min) in the screening of patients suspected with pSS, presenting with xerostomia in whom labial salivary gland biopsy (LSGB) should be performed. We will try to answer whether it is possible not to perform LSGB in targeted patients according to UWS results? We analyze the correlation between UWS value and focus score (FS) and anti-SSA antibodies.MethodsThe study group consisted of subjects above 18 years of age with a subjective feeling of oral dryness.ResultsA total of 105 subjects were qualified for the study. The final diagnosis of pSS was made in 44 patients according to the classification criteria from 2016. No age differences were identified between pSS patients and control group subjects (patients with dry mouth without autoimmune background). UWS rates were significantly lower in pSS patients than in the control group. No association was identified between UWS and focus score (FS) ≥ 1 in LSGB. No differences were observed between anti-SSA-positive and anti-SSA-negative patients in terms of age, UWS rates, FS.ConclusionLSGB should be performed in all suspected pSS cases regardless of the UWS rate value, particularly in subjects without specific anti-SSA antibodies. In patients with suspected pSS, only less than one-half of the UWS measurements are below the value of 0.1 mL/min adopted as the threshold in the classification criteria for pSS.
Highlights
Xerostomia is one of the main symptoms of Sjögren’s syndrome (SS)
Our study results indicate that UWS rates are significantly lower in the group of patients with confirmed primary Sjögren’s syndrome (pSS) compared to those with subjective xerostomia without autoimmune background
Only less than one-half of the measurements are below the value of 0.1 mL/min adopted as the threshold in the classification criteria at the time of diagnosis
Summary
Xerostomia is one of the main symptoms of Sjögren’s syndrome (SS). Xerostomia is the subjective sensation of dry mouth, which is often, but not always, associated with hypofunction of the salivary glands. The unstimulated salivary flow (UWS) test is one of the objective SS classification criteria used to assess the severity of salivary glands’ hypofunction. A salivary flow rate of ≤ 0.1 mL/min is considered an abnormal result typical for SS. This value was first specified in the classification criteria established more than twenty years ago [2] and has not been changed to date. An increasing number of studies is being published in which the authors prove that UWS values are age- and gender-dependent [3, 4].
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