Abstract
ATP-Binding Cassette (ABC) transporters are involved in cholesterol metabolism and their dysfunctions could lead to obesity-associated complications. It was investigated whether SNPs in the ABCA1 (rs1800977 and rs2230806), ABCA7 (rs2279796) and ABCG1 (rs692383 and rs3827225) genes can modulate the responsiveness of 137 obese women to a weight-loss dietary intervention. Thus, anthropometric and lipid profiles were collected at baseline and after nine weeks of a calorie-restricted diet of 600kcal per day and participants were genotyped for the ABC genes SNPs. Regarding the transversal analysis, the ABCA7 rs2279796 GG genotype was associated with higher levels of total cholesterol and LDL-c at baseline (p = 0.044 for both). Association between ABCG1 rs692383 AA genotype and lower BMI were found in the post-diet moment, however, statistical significance was lost after multi-test correction. Regarding the longitudinal analysis, after multi-test correction, the association remained between ABCG1 rs692383 G allele and HDL-c levels: G allele carriers had a lower HDL-c reduction (p = 0.043). Results suggest the standard weight-loss diet applied in this study could attenuate the ABCA7 rs2279796 GG genotype effects found at baseline and non-dyslipidemic obese women with ABCG1 rs692383 G allele are benefitting from the diet with a lower reduction in HDL-c levels.
Highlights
Lipid homeostasis is an important protective factor against several diseases, such as obesity, dyslipidemia, cardiovascular diseases, type 2 diabetes and inflammation (Lee et al, 2003)
The aim of this study was to verify whether single nucleotide polymorphisms (SNPs) in the ABCA1, ABCA7 and ABCG1 genes influence variables related to obesity and lipid profile in obese women and to evaluate the effect of these SNPs on anthropometric and lipid parameters in response to a weight-loss dietary intervention
The dietary intervention resulted in reduction of weight, BMI, waist circumference, abdominal circumference, total cholesterol and high-density lipoprotein (HDL)-c (p < 0.01 for all) (Table 2)
Summary
Lipid homeostasis is an important protective factor against several diseases, such as obesity, dyslipidemia, cardiovascular diseases, type 2 diabetes and inflammation (Lee et al, 2003). Correct functioning of many gene products is involved in the lipid homeostasis, among these genes are the ATP-Binding Cassette (ABC) transporters. The ABC transporters are cell membrane proteins which use the energy from ATP hydrolysis to transport molecules from inside or outside of cell (Wilkens, 2015). These proteins transport many molecules, such as polysaccharides, proteins, vitamins, hormones, oligonucleotides and lipids (Kaminski et al, 2000; Wilkens, 2015). The correct operation of ABC transporters is essential to maintain body homeostasis, especially regarding the cholesterol metabolism
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