Is HbA1c level affected by high triglyceride levels?

Abstract

Aim: Diabetic patients have atherogenic dyslipidemia characterized by increased triglyceride, increased low-density lipoprotein (LDL) cholesterol, and low-density lipoprotein (HDL) cholesterol. Lipoprotein abnormalities explain the increased risk of coronary artery disease in patients with diabetes. It is estimated that 30-60% of patients with type 2 diabetes have dyslipidemia. The high HbA1c value indicates that the risk of complications may be increased in addition to poor glycemic control, but it is also important in terms of investigating the patient for dyslipidemia and treating appropriate patients. In this study, we planned to investigate whether HbA1c is affected by high triglyceride values and whether triglyceride elevation may indicate low HbA1c. Material and Methods: In this study, Diabetic patients aged between 18-65 years with HbA1c > 6.5 who applied to Diyarbakir Gazi Yasargil Training and Research Hospital Internal Medicine Clinic between July 2017 and July 2019 were included. Results: In our study we found a negative relationship between the age of our patients and HbA1c, glucose and triglycerides. There was a linear correlation between HbA1c and triglyceride. In parallel with the rise of triglyceride, there was also an increase in HbA1c.As glucose and triglyceride increased, HbA1c also increased. Conclusion: HbA1c level was not affected by elevated triglyceride and did not cause low results. We also think that the decrease in triglyceride, HbA1c and glucose levels with age and the increase in triglyceride level as HbA1c level increases are the most important data of our study. We think that this study is valuable in terms of demonstrating that failure of glucose regulation in diabetic patients adversely affects lipid profile.