Abstract
Commonly recognized clinical sub-types of cataract are nuclear, cortical and posterior subcapsular types (PSC). However, it is not very clear how these clinical sub-types correspond to distinct etiological entities. The current theories developed on cataract formation do not distinguish between the clinical sub-types . Surprisingly, many biochemical changes in the lens that cause cataract are also found in aging lenses with normal clarity 3 .
Highlights
Age related cataract is the major cause of low vision and blindness in the world today[1] with 17 million bilaterally blind in 1990 2.Commonly recognized clinical sub-types of cataract are nuclear, cortical and posterior subcapsular types (PSC)
Sorbitol accumulations in the lens causes increased osmotic pressure causing cell damage that lead to opacification but clinical studies have shown a failure for aldose reductase inhibitors to prevent cataract in human lens 8
90% of cataract surgeries of Galle District had been performed at the public sector institution
Summary
Age related cataract is the major cause of low vision and blindness in the world today[1] with 17 million bilaterally blind in 1990 2. Recognized clinical sub-types of cataract are nuclear, cortical and posterior subcapsular types (PSC). Many biochemical changes in the lens that cause cataract are found in aging lenses with normal clarity 3. Reactive oxidizing chemicals such as superoxide, hydrogen peroxide and hydroxyl radicals are toxic to biomolecules and are capable of producing cataract due to oxidative stress. Sorbitol accumulations in the lens causes increased osmotic pressure causing cell damage that lead to opacification but clinical studies have shown a failure for aldose reductase inhibitors to prevent cataract in human lens 8. It provides an important and useful estimate of potential cataract burden in a population and different distributions 11
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