Abstract
Recent reports have suggested that extramedullary (EM) relapse of acute myeloid leukemia (AML) post-hematopoietic stem cell transplantation (HSCT), unlike isolated bone marrow (BM) relapse, is associated with improved prognosis. We reviewed the outcomes of relapsed AML post-HSCT at our institution to determine whether survival for patients with EM relapse was truly improved in comparison to patients suffering BM relapses treated in a similar (active) way. Outcomes of all 274 allogeneic HSCT performed for adult AML between 2000 and 2010 at our institution were retrospectively reviewed. As of January 2011, 72 relapses post-HSCT had occurred, including 64 BM relapses (89%), two concomitant BM and EM relapses (3%), and six EM relapses alone (8%). EM relapses occurred significantly later post-HSCT than BM relapses (median 25.2 vs 3.9 months, respectively; P = 0.001). Patients suffering an EM relapse were significantly more likely to receive active therapy at relapse (7/8; 88%) than those suffering a BM relapse alone (28/64; 44%; P = 0.026). When survival analysis was restricted to outcomes of patients treated actively (i.e., with curative intent), no difference in outcome between EM and BM relapses was observed (median survival 13.5 vs 8 months for EM vs BM relapses, respectively, P = 0.44). Our results suggest that EM relapse post-HSCT has similar outcomes to BM relapses treated in a similar way. Furthermore, choice of therapy at relapse appears related to the time post-HSCT that the relapse occurs, with BM relapses occurring significantly earlier post-HSCT than relapses at EM sites.
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