IS CONTRACEPTIVE INJECTION CAUSE BREAST CANCER? : META ANALYSIS

Abstract

Background: Injectable hormonal contraception was a major risk factor for breast cancer. The content of the progestin hormone in injection hormonal contraceptives can affect the uncontrolled growth of breast tissue, leading to breast cancer. This study aims to analyze the magnitude of the effect of injection hormonal contraception on the incidence of breast cancer with a meta-analysis study. Method: This research is a systematic review and used a Prisma flow diagram. The process of searching for articles through a database of journals which includes: PubMed, Science Direct, and Google Scholar by selecting articles published in 2010-2020. Keywords used include: “ Women Aged 15-80 Years” OR “Women of Menopause” AND “Birth control injections” AND “Breast Cancer”. The inclusion criteria included full-text articles with a case-control study design, articles using English, and multivariate analysis with adjusted odds ratios. Artikel fulfills the requirements for analysis using Revman 5.3 Result: There were 6 articles with the case-control study. A meta-analysis of 6 case-control studies showed that the use of injectable hormonal contraception had a 1.37 times risk of developing breast cancer compared with women using non-hormonal contraception (aOR 1.37; 95% CI 1.09 to 1.71; p = 0.006). Conclusion: Injectable hormonal contraceptives can increase the incidence of breast cancer.