Abstract
Iron is an essential nutrient for bacterial survival and replication. Interfering with iron metabolism is a potential nondrug-resistant antibacterial strategy. Here we propose an iron-blocking antibacterial therapy (IBAT) based on cationic heme-mimetic gallium porphyrin (Ga-CHP). Cations and heme bionics facilitated the uptake of Ga-CHP by bacteria through heme metabolism and are the primary motifs for its broad-spectrum antibacterial activity. Ga-CHP can rapidly kill gram-positive and gram-negative strains, even multidrug-resistant strains. Notably, unlike antibiotics, it is hard for bacteria to evolve drug resistance in terms of phenotypes and mutations. Furthermore, Ga-CHP is also a superior photosensitizer and its antibacterial capability can be further enhanced via synergistic photodynamic therapy in vitro and in vivo due to heme-assisted catalase inactivation. This work presents an innovative antibacterial strategy for addressing antibiotic resistance crisis and enhancing photodynamic antibacterial activity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
