Iron oxide (Fe3O4) and ciprofloxacin loaded magnetic nanoparticles for magnetic drug targeting

Abstract

Iron oxide (Fe3O4) pristine and ciprofloxacin loaded nanoparticles are synthesized successfully using co-precipitation method. X-ray diffraction analysis confirms the pure phase formation of the synthesized Fe3O4 particles. The grain size of the Fe3O4 calculated from the SEM images comes out to be 50 nm. UV-VIS spectrophotometric analysis indicates the accuracy of the results in which an absorption maximum of blank and ciprofloxacin containing iron oxide (Fe3O4) particle was observed at 260 and 265 nm respectively. The spectrum band shows the maximum absorption band shift of around 4-5 nm which may be explained by the drug conjugation to the Fe3O4 nanoparticles. The spectrum indicates the formation of Fe3O4 magnetic nanoparticles having black color and obtained material is found with energy band gap (E) of 2.12 eV and 2.19 eV. On the basis of the findings from dynamic light scattering (DLS) results, it can be concluded that overall particle size of magnetic iron oxide nanoparticles is observed as 765 nm. In the present study the polydispersity index (P.I.) of bare Fe3O4 magnetic nanoparticles is 0.221, which indicate the hydrodynamic property of the synthesized particles.