Abstract
Objective: to define the mechanisms of impaired biological rhythms of iron exchange and lipid peroxidation (LPO) and to develop criteria for predicting the outcomes of pyoseptic complications. Subjects and methods. A hundred and seventeen patients with a good course of sepsis and its complication as multiple organ dysfunction (MOD) (a study group) and 108 healthy males (a control group) were examined. Twenty-four changes in the concentrations of total and ferrous iron (Fe2+) in the serum and urine, in those of OZhSS, malonic dialdehyde (MDA), MSM260 and MSM280 in the serum, urine, and red blood cells were studied. Results. With the good course of sepsis, iron exchange desynchronism was shown to be caused by elevated Fe2+ and MDA concentrations and enhanced proteolysis. The processes of renal MSM detoxification and elimination were ascertained to play an important role in the prediction of a good outcome of sepsis. With the poor course of sepsis and its complication as MOD, considerable rises in Fe2+, MDA, and MSM mesors were followed by their rhythm inversion and diminished MSM excretion due to progressive acute renal failure. Conclusion. The desynchronized exchange of iron was found to be due to the intensive increase in its fraction that triggers LPO and membrane destructive processes. On this basis, the authors have developed a procedure for predicting the course of sepsis and its complication as MOD, which allows the risk of complications and death rates to be substantially reduced during pyoseptic processes.
Highlights
Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΠΎΡΡΠΈ Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ Π±ΠΈΠΎΡΠΈΡΠΌΠΎΠ² ΠΎΠ±ΠΌΠ΅Π½Π° ΠΆΠ΅Π»Π΅Π·Π° ΠΈ ΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π°ΡΠΈΠΈ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ² ΠΏΡΠΈ ΡΠ΅ΠΏΡΠΈΡΠ΅ ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°ΡΡ ΠΊΡΠΈΡΠ΅ΡΠΈΠΈ Π΄Π»Ρ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈΡΡ ΠΎΠ΄ΠΎΠ² Π³Π½ΠΎΠΉΠ½ΠΎ ΡΠ΅ΠΏΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ
The processes of renal MSM detoxification and elimina tion were ascertained to play an important role in the prediction of a good outcome of sepsis
With the poor course of sepsis and its complication as multiple organ dysfunction (MOD), considerable rises in Fe2+, malonic dialdehyde (MDA), and MSM mesors were followed by their rhythm inversion and diminished MSM excretion due to progressive acute renal failure
Summary
Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΠΎΡΡΠΈ Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ Π±ΠΈΠΎΡΠΈΡΠΌΠΎΠ² ΠΎΠ±ΠΌΠ΅Π½Π° ΠΆΠ΅Π»Π΅Π·Π° ΠΈ ΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π°ΡΠΈΠΈ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ² ΠΏΡΠΈ ΡΠ΅ΠΏΡΠΈΡΠ΅ ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°ΡΡ ΠΊΡΠΈΡΠ΅ΡΠΈΠΈ Π΄Π»Ρ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈΡΡ ΠΎΠ΄ΠΎΠ² Π³Π½ΠΎΠΉΠ½ΠΎ ΡΠ΅ΠΏΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ. ΠΠ° ΡΡΠΎΠΉ ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΡΠΏΠΎΡΠΎΠ± ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ΅ΡΠ΅ Π½ΠΈΡ ΡΠ΅ΠΏΡΠΈΡΠ° ΠΈ Π΅Π³ΠΎ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ ΠΏΠΎΠ»ΠΈΠΎΡΠ³Π°Π½Π½ΠΎΠΉ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠ΅ΠΉ, ΡΡΠΎ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ ΡΠ½ΠΈΠ·ΠΈΡΡ ΡΠΈΡΠΊ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΎΡΠ»ΠΎΠΆ Π½Π΅Π½ΠΈΠΉ ΠΈ Π»Π΅ΡΠ°Π»ΡΠ½ΠΎΡΡΡ ΠΏΡΠΈ Π³Π½ΠΎΠΉΠ½ΠΎ ΡΠ΅ΠΏΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ . The desynchronized exchange of iron was found to be due to the intensive increase in its fraction that triggers LPO and membrane destructive processes On this basis, the authors have developed a procedure for predicting the course of sepsis and its complication as MOD, which allows the risk of complications and death rates to be substantially reduced during pyoseptic processes. Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ β ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΠΎΡΡΠΈ Π½Π°ΡΡ ΡΠ΅Π½ΠΈΠΉ Π²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΈ ΠΎΠ±ΠΌΠ΅Π½Π° ΠΆΠ΅Π»Π΅Π·Π° ΠΈ ΠΏΠ΅ΡΠΎΠΊ ΡΠΈΠ΄Π°ΡΠΈΠΈ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ² ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°ΡΡ ΠΊΡΠΈΡΠ΅ΡΠΈΠΈ Π΄Π»Ρ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈ ΡΠΎΠ²Π°Π½ΠΈΡ ΠΈΡΡ ΠΎΠ΄Π° Π³Π½ΠΎΠΉΠ½ΠΎ ΡΠ΅ΠΏΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ
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