Iron-catalyzed carbonylative synthesis of tert-alkyl thioesters

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In the context of transition metal-catalyzed carbonylation reactions, iron-catalyzed carbonylative transformation retains considerable value due to its high abundance, affordability, and diverse catalytic modes. Among the carbonylation reactions, non-activated bulky alkyl halides and highly reactive thiol compounds are considered to be particularly challenging substrates. In this study, we studied the synthesis of various steric alkyl thioesters through the reaction of non-activated steric alkyl iodides with S-aryl thioester as the aryl sulfur source catalyzed by iron salt. This reaction offers a convenient approach for the synthesis of hindered thioesters. Preliminary mechanistic studies indicated the involvement of radical intermediates.