Abstract
Ocular metastasis is relatively uncommon, with a reported incidence of approximately 8%, according to the results of autopsy evaluation. The majority of ocular metastases are located within the choroid, while metastatic tumors affecting the iris are rare. Metastatic tumors may manifest as stromal nodules or ill-defined iris thickening, or they may present with nonspecific features such as pain, iridocyclitis, and hyphema. Here, we describe three patients with iris metastasis and discuss the diagnostic challenges and unusual findings associated with these cases.
Highlights
Uveal metastasis of systemic carcinoma to the eye is estimated to occur in 8% of cases, according to the results of autopsy evaluations where microscopic detection rate is reported[1]
Metastatic tumors to the iris are relatively uncommon; they may present as stromal nodules or ill-defined iris thickening, or they may be associated with atypical features such as pain, iridocyclitis, and hyphema[4,5]
Ultrasound biomicroscopy (UBM) of the right eye revealed an iridociliary mass with homogeneous reflectivity, featuring areas of internal hyporeflective spaces within the tumor with clear margins (Figure 1 B)
Summary
Uveal metastasis of systemic carcinoma to the eye is estimated to occur in 8% of cases, according to the results of autopsy evaluations where microscopic detection rate is reported[1]. In 2014, Shields et al reported their 40-year experience of 104 cases of iris metastases arising from systemic cancer, demonstrating the breast, lung, and skin as the most common primary sites for such lesions[4]. A 61-year-old man presented with a 3-month history of blurred vision affecting the right eye and the presence of iris lesion. Ocular examination revealed a best-corrected vision of 20/30 in the right eye and 20/20 in the left eye.
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