Abstract
The present study examined the effect of iptakalim (Ipt), a novel ATP-sensitive potassium (K ATP) channel opener (KCO), on 1-methyl-4-phenylpyridinium ion (MPP +)-induced dopamine (DA) and glutamate efflux in extracellular fluid of rat striatum, using microdialysis technique. Rats were implanted guide cannula in the striatum and artificial cerebrospinal fluid was infused through a microdialysis probe to detect the level of DA and glutamate in the striatum. MPP + significantly enhanced the extracellular levels of DA and its metabolites, DOPAC and HVA, as well as glutamate. Application of Ipt (1, 10, 100 μM) concentration-dependently suppressed DA and its metabolites efflux induced by MPP +. Concomitantly, Ipt reduced the increase of extracellular glutamate induced by MPP +. These results suggest that Ipt can regulate DA and glutamate efflux induced by MPP + in rat striatum.
Published Version
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