Ion-selective electrode response in biologic fluids.

Abstract

The response of ion-selective electrodes in biological fluids may be affected by a wide variety of physical and chemical factors. These may influence the indicator electrode directly or may affect the liquid junction of the reference electrode. A brief discussion is presented of the various sources of error and uncertainty in electrode measurements in biologic media especially with micro-electrodes. A serious need exists for the development of practical standards for the calibration of ion-selective electrodes in physiologic media in order to ensure the consistency of inter-laboratory measurements.