Abstract
The construction and electroanalytical characteristics of ion-selective electrodes (ISEs) for the quantitative determination of furacilin, furadonin, and furagin are described. Ion association complexes of the drugs with N,N,N, N-tetradecylammonium were tested as electroactive materials for ionometric sensors. These ISEs show a linear response to drugs over a concentration range from 10−5 to 10−1 mole/liter with anionic slopes from 51 to 58 mV/pC and possess low drug determination limits (∼5 × 10−6 mole/liter). The ISEs exhibit fast response, good stability, and reasonable selectivity. The proposed ISEs were successfully used for direct potentiometric analysis of furacilin, furadonin, and furagin in ready-to-use pharmaceutical preparations.
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