Ionic Liquid Modified Carbon Paste Sensor Electrode for Determination of Antihypertensive Drug

Abstract

Electrochemical sensor was fabricated based on carbon paste electrode modified with an ionic liquid crystal ILC (2-chloro-1,3-dimethyl –imidazolidinium hexafluoro phosphate) in presence of sodium dodecyl sulfate for the electrochemical determination of Terazosin (TR). The electrode performance was compared in presence of other ionic liquids ILs (1-Butyl-4-methyl pyridinium tetrafluoroborate) and (1-n-Hexyl-3-methyl imidazolium tetrafluoroborate). Ultrasensitive determination of Terazosin HCl at the ILC modified electrode in the linear dynamic ranges of 0.002 to 0.09 μmol L−1 and 0.1 to 30 μmol L−1 with correlation coefficients 0.996 and 0.995 and LODs 1.69 ´ 10-11 mol L-1 and 6.43 ´ 10-9 mol L− 1, respectively were achieved. Selective determination of TR in presence of uric acid and ascorbic acid and simultaneous sensing of binary mixtures of TR/dopamine, TR/paracetamol and TR/Morphine were also realized successfully using the modified sensor.