Abstract
Electrochemical sensor was fabricated based on carbon paste electrode modified with an ionic liquid crystal ILC (2-chloro-1,3-dimethyl-imidazolidinium hexafluorophosphate) in presence of sodium dodecyl sulfate for the selective electrochemical determination of Terazosin (TZ) in presence of common interference compounds. The electrode performance was compared in presence of other ionic liquids ILs (1-Butyl-4-methyl pyridinium tetrafluoroborate) and (1-n-Hexyl-3-methyl imidazolium tetrafluoroborate). Ultrasensitive determination of Terazosin HCl at the ILC modified electrode in the linear dynamic ranges of 0.002 to 0.09 μmol·L−1 and 0.2 to 30 μmol·L−1 with correlation coefficients 0.996 and 0.995 and LODs 1.69 × 10−11 mol·L−1 and 6.43 × 10−9 mol·L−1, respectively, were obtained. Selective determination of TZ in presence of uric acid and ascorbic acid and simultaneous determination of binary mixtures of TZ/dopamine, TZ/paracetamol and TZ/Morphine were also determined successfully using the modified sensor.
Highlights
Terazosin hydrochloride (TZ), 2-[4-(2-tetrahydrofuranyl) carbonyl]-1-piperazinyl-6,7-di-methoxy4-quinazolinamine monohydro-chloride dehydrate, an alpha-1-selective adrenoceptor blocking agent, is a quinazoline derivative which is used to treat hypertension [1,2] and for the treatment of symptoms of an enlarged prostate [3,4]
Several methods for determination of this drug have been reported in the literature, including high performance liquid chromatography [5,6,7,8,9,10,11,12,13,14,15,16], capillary zone electrophoresis [17], spectrofluorimetry [18,19], X-ray fluorescence spectrometry based on the formation of ion-pair associates with zinc thiocyanate [20] and voltammetric methods [19,20]
This study presents for the first time a sensitive sensor based on carbon paste electrode in situ modified with Ionic liquid crystals (ILCs)(2-chloro-1,3-dimethyl-imidazolidinium hexafluorophosphate) for the electrochemical determination of TZ in the presence of surface active agent
Summary
Terazosin hydrochloride (TZ), 2-[4-(2-tetrahydrofuranyl) carbonyl]-1-piperazinyl-6,7-di-methoxy4-quinazolinamine monohydro-chloride dehydrate, an alpha-1-selective adrenoceptor blocking agent, is a quinazoline derivative which is used to treat hypertension (high blood pressure) [1,2] and for the treatment of symptoms of an enlarged prostate [3,4]. The modified carbon paste ionic liquid electrodes (CPILEs) shows high conductivity and electron transfer rate, wide electrochemical window and low over potentials [32,33,34,35] and very good electro-catalytic activities towards determination of many probes in electrochemistry [36], gas and liquid chromatography [37], mass spectrometry [38], capillary electrophoresis [39] and sensors [40,41,42,43,44,45,46,47]. This study presents for the first time a sensitive sensor based on carbon paste electrode in situ modified with ILC(2-chloro-1,3-dimethyl-imidazolidinium hexafluorophosphate) for the electrochemical determination of TZ in the presence of surface active agent. The determination of TZ in spiked urine samples is achieved with good reproducibility and excellent recovery results demonstrating the validity of this method for real sample analysis at the proposed electrode
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