Abstract
Abstract Recently the use of ion-pairing of inorganic and organic ions to ionic surfactants has been exploited in Fast Atom Bombardment Mass Spectrometry (FAB-MS) in order to increase secondary ion emission. Hydrophilic organic ions, such as 6-aminopenicillanic acid (6-APA), can be selectively ‘bound’ to the surface of a hydrophilic FAB matrix such as glycerol via interaction with an ionic surfactant of opposite charge. Thus, ion-pairing of analyte to surfactant allows for utilization of the surface specificity of FAB. In order to assess the utility and limitations of ion-pairing in FAB, we studied the secondary ion emission characteristics of a cation exchange model system consisting of the quaternary ammonium salt choline chloride (CC), the surfactant octyl sodium sulfate (OSS), and glycerol. Large, weakly solvated ions such as the tetramethylammonium ion of choline readily exchange sodium from sulfonate based cation exchange resins. Cation affinity for sulfate in increasing order is Li+< H+< Na+< NH4 +...
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