Ion Mobility–Mass Spectrometry

Abstract

Abstract Ion mobility spectrometry (IMS) is a powerful analytical technique that has gained widespread use in the last few decades. The coupling of IMS with mass spectrometry (MS) greatly extends the capabilities and applications of the technique. This coupled technique, ion mobility–mass spectrometry (IM‐MS), has found utility in obtaining structural information on a variety of molecules with sizes spanning polyatomic ions to viruses. IM‐MS instruments are more routinely used as combined structurally selective and mass‐selective analytical separation devices allowing complex mixtures to be investigated. Furthermore, IM‐MS separations are conducted in the gas phase, which provides fast measurement capabilities that allow it to be compatible with other front‐end, condensed‐phase analytical separations, such as liquid chromatography and capillary electrophoresis. This article provides a general overview of IM‐MS technology, notable advances in instrumentation, and examples of several applications across a broad range of fields.